Geographically, the region extends southward from Japan's northernmost island to New Zealand's southernmost island, and eastward from Myanmar's western border to Samoa, the Cook Islands and Tahiti.

Asia-Pacific Region is home to 40% of earth's people. Much of the region lies within the "10/40 Window" that encompasses many of earth's un-evangelized and under-evangelized people groups. Within the region are earth's most populous nation, its most Muslim nation, and its most Buddhist nation.

The Church of the Nazarene's 45 districts in the 25 nations of the region where it is, with its 13 institutions of higher education, strives to fulfill its Christ-mandated mission.